Pathogenic mutations cause rhodopsin to misfold and disrupt its function. In this study, a yeast-based assay was used to screen for compounds that have the potential to rescue the function of mutant rhodopsin. It was confirmed that 9-cis retinal could partially rescue light-dependent activation of disease-associated rhodopsin mutation (P23H). A phenotypic screen was also done with yeast assays to screen compounds from the LOPAC1280 library and a peptidomimetic library.
- Convergent patterns of evolution of mitochondrial oxidative phosphorylation (OXPHOS) genes in electric fishes January 16, 2020
- Screening of Chemical Libraries Using a Yeast Model of Retinal Disease October 7, 2019
- Evolutionary signatures of photoreceptor transmutation in geckos reveal potential adaptation and convergence with snakes October 7, 2019
- To see or not to see: molecular evolution of the rhodopsin visual pigment in neotropical electric fishes October 4, 2019
- Coupling of human rhodopsin to a yeast signaling pathway October 4, 2019
Tweets by Belinda Chang’s Lab (@opsinlab)My Tweets