Pathogenic mutations cause rhodopsin to misfold and disrupt its function. In this study, a yeast-based assay was used to screen for compounds that have the potential to rescue the function of mutant rhodopsin. It was confirmed that 9-cis retinal could partially rescue light-dependent activation of disease-associated rhodopsin mutation (P23H). A phenotypic screen was also done with yeast assays to screen compounds from the LOPAC1280 library and a peptidomimetic library.
- Screening of Chemical Libraries Using a Yeast Model of Retinal Disease October 7, 2019
- Evolutionary signatures of photoreceptor transmutation in geckos reveal potential adaptation and convergence with snakes October 7, 2019
- To see or not to see: molecular evolution of the rhodopsin visual pigment in neotropical electric fishes October 4, 2019
- Coupling of human rhodopsin to a yeast signaling pathway October 4, 2019
- Functional trade-offs and environmental variation shaped ancient trajectories in the evolution of dim-light vision October 3, 2019
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