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Recent Posts
- Scaling up functional analyses of the G protein-coupled receptor rhodopsin March 13, 2024
- Evolution of a novel regulatory mechanism for hypoxia tolerance in electric fishes March 13, 2024
- Multiple ecological axes drive molecular evolution of cone opsins in Beloniform fishes March 13, 2024
- Adaptive evolution of nearctic deepwater fish vision: implications for assessing functional variation for conservation March 13, 2024
- Convergent Evolution of Dim Light Vision in Owls and Deep-Diving Whales November 28, 2023
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Category Archives: Uncategorized
Scaling up functional analyses of the G protein-coupled receptor rhodopsin
Eukaryotic cells use G protein-coupled receptors (GPCRs) to convert external stimuli into internal signals to elicit cellular responses. GPCRs are critical to many biological processes; however, the effect of mutations in GPCR-coding genes on GPCR activation and downstream signaling pathways … Continue reading
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Evolution of a novel regulatory mechanism for hypoxia tolerance in electric fishes
Hypoxia, or a lack of oxygen in the tissues, is a significant source of metabolic stress. It is a major component of many human diseases, including various forms of cancer. Remarkably, there are animals that display an impressive capacity to … Continue reading
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Multiple ecological axes drive molecular evolution of cone opsins in Beloniform fishes
Beloniformes, the order including needlefishes, flying fishes, halfbeaks, and allies, comprise over 200 species occupying a wide array of habitats—from the marine epipelagic zone to tropical rainforest rivers. These fish also exhibit a variety of diets, including piscivory, herbivory, and … Continue reading
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Adaptive evolution of nearctic deepwater fish vision: implications for assessing functional variation for conservation
Intraspecific functional variation, the functional variation of a trait within a species, is critical for adaptation to rapidly changing environments. Ciscoes and Deepwater Sculpin are two lineages of North American deep-dwelling fish that recently, less than 15,000 years ago, began … Continue reading
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Whales Evolved Swiftly to Become Deep Divers
Awesome news article from the CSB department at UofT highlighting a recent PNAS paper from the Chang lab, featuring the work of former PhD student Sarah Dungan! Many cetacean species can dive to extraordinary depths on a single breath, but … Continue reading
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This Fish Has Adapted to Canada’s Deepest Coldest Lakes. UTSC Researchers are Unravelling it’s Genetics to Find Out How.
Great article from UTSC covering the incredible work Alex Van Nynatten, a postdoc in the Lovejoy lab, has been doing with the Deepwater Sculpin in collaboration with the Chang lab! This fish is quite impressive as they are known to … Continue reading
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Convergent patterns of evolution of mitochondrial oxidative phosphorylation (OXPHOS) genes in electric fishes
The ability to generate and detect electric fields is vital for the survival of several groups of fishes. Authors Ahmed A. Elbassiouny, Nathan R. Lovejoy and Belinda S.W. Chang speculated that electric fish may be able to meet the high … Continue reading
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Screening of Chemical Libraries Using a Yeast Model of Retinal Disease
Pathogenic mutations cause rhodopsin to misfold and disrupt its function. In this study, a yeast-based assay was used to screen for compounds that have the potential to rescue the function of mutant rhodopsin. It was confirmed that 9-cis retinal could … Continue reading
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Evolutionary signatures of photoreceptor transmutation in geckos reveal potential adaptation and convergence with snakes
A recent study by Ryan K. Schott, Nihar Bhattacharyya, and Belinda S.W. Chang analysed the patterns of evolution in the gecko phototransduction gene and compared them to those of other reptiles. Parallel shifts in selective constraint on phototransduction genes were … Continue reading
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To see or not to see: molecular evolution of the rhodopsin visual pigment in neotropical electric fishes
What do visual disease in humans and dim-light adaptation in fishes have in common? Read our publication on Proceedings of the Royal Society B, and find out more!
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