- Convergent patterns of evolution of mitochondrial oxidative phosphorylation (OXPHOS) genes in electric fishes January 16, 2020
- Screening of Chemical Libraries Using a Yeast Model of Retinal Disease October 7, 2019
- Evolutionary signatures of photoreceptor transmutation in geckos reveal potential adaptation and convergence with snakes October 7, 2019
- To see or not to see: molecular evolution of the rhodopsin visual pigment in neotropical electric fishes October 4, 2019
- Coupling of human rhodopsin to a yeast signaling pathway October 4, 2019
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Convergent patterns of evolution of mitochondrial oxidative phosphorylation (OXPHOS) genes in electric fishes
The ability to generate and detect electric fields is vital for the survival of several groups of fishes. Authors Ahmed A. Elbassiouny, Nathan R. Lovejoy and Belinda S.W. Chang speculated that electric fish may be able to meet the high … Continue reading
Pathogenic mutations cause rhodopsin to misfold and disrupt its function. In this study, a yeast-based assay was used to screen for compounds that have the potential to rescue the function of mutant rhodopsin. It was confirmed that 9-cis retinal could … Continue reading
Evolutionary signatures of photoreceptor transmutation in geckos reveal potential adaptation and convergence with snakes
A recent study by Ryan K. Schott, Nihar Bhattacharyya, and Belinda S.W. Chang analysed the patterns of evolution in the gecko phototransduction gene and compared them to those of other reptiles. Parallel shifts in selective constraint on phototransduction genes were … Continue reading
To see or not to see: molecular evolution of the rhodopsin visual pigment in neotropical electric fishes
What do visual disease in humans and dim-light adaptation in fishes have in common? Read our publication on Proceedings of the Royal Society B, and find out more!
In this new assay, light dependent activation of the human rhodopsin protein initiates the yeast mating pathway and results in the signaling of a fluorescent reporter. This innovative technique allowed the authors to characterize a panel of known rhodopsin mutations … Continue reading
Functional trade-offs and environmental variation shaped ancient trajectories in the evolution of dim-light vision
How did epistasis affect the evolution of tetrapod dim-light vision? How does this compare with fishes? Find out more by reading our lab’s recent paper published in eLIFE.
How is bat color vision shaped by ecological factors? Check out our new paper in Proc B!
Can convergence in evolutionary rates predict convergence in protein function? Check out our new paper in Evolution!
Congratulations to Dr. Frances E. Hauser on our recently published invited review in the Current Opinion series!
A study by Raphaël Di Roberto, Belinda Chang and Sergio Peisajovich demonstrated that changes in ligand efficacy can lead to changes in GPCR specificity, eliminating the need for extensive binding pocket re-modeling. Read their paper published in Scientific Reports to … Continue reading