Elbassiouny, A.A., Buck, L.T., Abatti, L.E., Mitchell, J.A., Crampton, W.R., Lovejoy, N.R., & Chang, B.S.W. (2024). Evolution of a novel regulatory mechanism of hypoxia inducible factor (HIF1⍺) in hypoxia tolerant electric fishes.  Journal of Biological Chemistry, In press. PDF.

In the news for Elbassiouny et al 2024, ‘Evolution of a novel regulatory mechanism of hypoxia inducible factor in hypoxia tolerant electric fishes

Scott, B.M., Chen, S.K., Van Nynatten, A., Liu, J., Schott, R.K., Heon, E., Peisajovich, S.G., & Chang, B.S.W. (2024). Scaling up functional analyses of the G protein-coupled receptor rhodopsin. Journal of Molecular Evolution, 92(1):61-71. PDF.

Chau, K.D., Hauser, F.E., Van Nynatten, A., Daane, J.M., Harris, M.P., Chang, B.S.W., & Lovejoy, N.R. (2024). Multiple ecological axes drive molecular evolution of cone opsins in Beloniform fishes. Journal of Molecular Evolution, 92(2). PDF.

Van Nynatten, A., Duncan, A.T., Lauzon, R., Sheldon, T.A., Chen, S.K., Lovejoy, N.R., Mandrak, N.E., & Chang, B.S.W. (2024). Adaptive evolution of Nearctic deepwater fish vision: Implications for assessing functional variation for conservation. Molecular Biology and Evolution, 41(2):msae024. PDF.

Macpherson, E.S.B., Hauser, F.E., Van Nynatten, A., Chang, B.S.W., & Lovejoy, N.R. (2023). Evolution of rhodopsin in flatfishes (Pleuronectiformes) is associated with depth and migratory behaviour. bioRxiv, 2023.11. 30.569440. PDF

Castiglione, G.M., Chiu, Y.L.I., Gutierrez, E.A., Van Nynatten, A., Hauser, F.E., Preston, M., Bhattacharyya, N., Schott, R.K., & Chang, B.S.W. (2023). Convergent evolution of dim light vision in owls and deep-diving whales. Current Biology. 33(21): 4733-4740. PDF.

Commentary on Castiglione et al 2023. ‘Convergent evolution of dim light vision in owls and deep-diving whales.’

In the news for Castiglione et al 2023, ‘Convergent evolution of dim light vision in owls and deep-diving whales.’

Castiglione, G.M., Hauser, F.E., Van Nynatten, A.V., & Chang, B.S.W. (2023). Adaptation of Antarctic Icefish Vision to Extreme Environments. Molecular Biology and Evolution, 40(4) msad030.PDF.

Commentary on Castiglione et al 2023. ‘Adaptation of Antartic Icefish Vision to Extreme Environments.’

Dungan, S.Z., & Chang, B.S.W. (2022). Ancient whale rhodopsin reconstructs dim-light vision over a major evolutionary transition: Implications for ancestral diving. Proceedings of the National Academy of Sciences USA, 119 (27) e2118145119. PDF.

Press for Dungan and Chang 2022U of T.

Hauzman, E., Pierotti, M.E.R., Bhattacharyya, N., Tashiro, J.H., Yovanovich, C.A.M., Campos, P.F., Ventura, D.F., Chang, B.S.W. (2021). Simultaneous Expression of UV and Violet SWS1 Opsins Expands the Visual Palette in a Group of Freshwater Snakes. Molecular Biology and Evolution. 30(12): 5225-5240. PDF.

Scott, B.M., Gutiérrez-Vázquez, C., Sanmarco, L.M., de Silva Pereira, J.A., Li, Z., Plasencia, A., Hewson, P., Cox, L.M., O’Brien, M., Chen, S.K., Moraes-Vieira, P.M., Chang, B.S.W., Peisajovich S.G., & Quintana, F.J. (2021). Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease. Nature Medicine. 27(7): 1212–1222. PDF.

Press for Scott et al 2021: U of T. The Scientist.

Van Nynatten, A., Castiglione, G.M., Gutierrez, E.A., Lovejoy, N.R. & Chang, B.S.W. (201). Recreated Ancestral Opsin Associated with Marine to Freshwater Croaker Invasion Reveals Kinetic and Spectral Adaptation, Molecular Biology and Evolution, 38(5): 2076–2087. PDF.

Press for Van Nynatten et al 2021: U of T.

Hauser, F.E., Ilves, K.L., Schott, R.K., Alvi, E., López-Fernández, H. & Chang, B.S.W. (2021). Evolution, inactivation and loss of short wavelength-sensitive opsin genes during the diversification of Neotropical cichlids. Molecular Ecology, 30(7): 1688-1703. PDF.

Henriques, L.D., Hauzman, E., Bonci, D.M.O., Chang, B.S.W., Muniz, J.A.P.C., Souza, G.S., Silveira, L.C.L., Galvao, O.F., Goulart, P.R.K., & Ventura, D.F. (2021). Uniform trichromacy in Alouatta caraya and Alouatta seniculus: behavioural and genetic colour vision evaluation. Frontiers in Zoology 18:36. PDF.

Simoes, B.F., Gower, D.J., Rasmussen, A.R., Sarker, M.A.R., Fry, G.C., Casewell, N.R., Harrison, R.A., Hart, N.S., Partridge, J.C., Hunt, D.M., & Chang, B.S.W., Pisani, D., & Sanders, K.L. (2020). Spectral diversification and trans-specific allelic polymorphism during the land-to-sea transition in snakes. Current Biology 30:2608-2615. PDF.

Liberles, D.A., Chang, B.S.W., Geiler-Samerotte, K., Goldman A., Hey, J., Kacar, B., Meyer, M., Murphy, W., Posada, D. & Storfer, A. (2020). Emerging frontiers in the study of molecular evolution. Journal of Molecular Evolution 88:211-226. PDF.

Elbassiouny, A.A., Lovejoy, N.R., Chang, B.S.W. (2019). Convergent patterns of evolution of mitochondrial oxidative phosphorylation (OXPHOS) genes in electric fishes. Philosophical Transactions B, 375:20190179. PDF.

Scott, B. M., Wybenga-Groot, L. E., McGlade, C. J., Heon, E., Peisajovich, S. G., & Chang, B. S. W. (2019). Screening of Chemical Libraries Using a Yeast Model of Retinal Disease. SLAS Discovery, 24(10): 969-977.PDF.

Schott R.K., Bhattacharyya N. & Chang B.S.W. (2019). Evolutionary signatures of photoreceptor transmutation in geckos reveal potential adaptation and convergence with snakes. Evolution, 73(9):1683-2032 PDF.

Van Nynatten, A., Janzen F.H., Brochu, K., Maldonado-Ocampo, J.A., Crampton, W.G.R., Chang, B.S.W. & Lovejoy, N.R. (2019). To see or not to see: molecular evolution of the rhodopsin visual pigment in neotropical electric fishes. Proceedings of the Royal Society B, 286: 20191182 PDF.

Scott, B.M., Chen, S.K., Bhattacharyya, N., Moalim, A.Y., Plotnikov, S.V., Heon, E., Peisajovich S.G. & Chang, B.S.W. (2019). Coupling of Human rhodopsin to a yeast signaling pathway enables characterization of mutations associated with retinal disease. Genetics, 211(2): 587-615 PDF.

Castiglione, G.M. & Chang, B.S.W. (2018). Functional trade-offs and environmental variation shaped ancient trajectories in the evolution of dim-light vision. ELIFE, 7:e35957 PDF.

Perry, B.W., Card, D.C., McGlothlin, J.W., Pasquesi, G.I.M., Adams, R.H., Schield, D.R., Hales, N.R., Corbin, A.B., Demuth, J.P., Hoffmann, F.G., Vandewege, M.W., Schott, R.K., Bhattacharyya N., Chang, B.S.W., Casewell, N.R., Whiteley, G., Reyes-Valesco, J., Mackessy, S.P., Gamble, T., Storey, K.B., Biggar, K.K., Passow, C.N., Kuo, C., McGaugh, S.E., Bronikowski, A.M., de Koning, J.,  Edwards, J.E., Pfrender, M.E., Minx, P., Brodie, III E.D., Brodie, E.D. Jr, Warren, W.C. & Castoe, T.A. (2018). Molecular adaptations for sensing and securing prey and insight into amniote genome diversity from the garter snake genome. Genome Biology and Evolution. 10(8):2110-2129. PDF.

Gutierrez, E.D.A., Castiglione, G.M., Morrow, J.M., Schott, R.K., Loureiro, L.O., Lim, B.K. & Chang, B.S.W. (2018). Functional shifts in bat dim-light visual pigment are associated with differing echolocation abilities and reveal molecular adaptation to photic-limited environments. Molecular Biology and Evolution 35(10):2422-2434.PDF.

Gutierrez, E.A., Schott, R.K., Preston, M.W., Loureiro, L.O., Lim, B.K. & Chang, B.S.W. (2018). The role of ecological factors in shaping bat cone opsin evolution. Proceedings of the Royal Society B, 285: 20172835. PDF.

Schott, R.K., Van Nynatten, A., Card, D.C., Castoe, T.A. & Chang, B.S.W.(2018). Shifts in selective pressures on snake phototransduction genes associated with photoreceptor transmutation and dim-light ancestry. Molecular Biology and Evolution35(6), 1376-1389.PDF.

Castiglione, G.M., Schott, R.K., Hauser, F.E. & Chang, B.S.W. (2018). Convergent selection pressures drive the evolution of rhodopsin kinetics at high altitudes via nonparallel mechanisms. Evolution, 72 (1): 170-186.PDF.

Di Roberto, R.B., Chang, B.W.S. & Peisajovich, S.G. (2017). The directed evolution of ligand specificity in a GPCR and the unequal contributions of efficacy and affinity. Scientific Reports, 7 : 16012. PDF.

Hauser, F.E. & Chang, B.S.W. (2017). Insights into visual pigment adaptation and diversity from model ecological and evolutionary systems. Current Opinion in Genetics & Development, 47: 110-120.PDF.

Hauser, F.E., Ilves, K.L., Schott, R.K., Castiglione, G.M., López-Fernández, H. & Chang, B.S.W. (2017). Accelerated evolution and functional divergence of the dim light visual pigment accompanies cichlid colonization of Central America. Molecular Biology and Evolution, 34 (10): 2650-2664.PDF.

Castiglione, G.M., Hauser, F.E., Liao, B.S., Lujan, N.K., Van Nynatten, A., Morrow, J.M., Schott, R.K., Bhattacharyya, N., Dungan, S.Z. & Chang, B.S.W. (2017). Evolution of nonspectral rhodopsin function at high altitudes. Proceedings of the National Academy of Sciences of the United States of America, 114 (28): 7385-7390.PDF.

Morrow, J.M., Castiglione, G.M., Dungan, S.Z. Tang, P.L., Bhattacharyya, N., Hauser F.E. & Chang, B.S.W. (2017). An experimental comparison of human and bovine rhodopsin provides insight into the molecular basis of retinal disease. FEBS Letters, 591: 1720-1731.PDF.

Bhattacharyya, N., Darren, B., Schott, R.K., Tropepe, V. & Chang, B.S.W. (2017). Cone-like rhodopsin expressed in the all-cone retina of the colubrid pine snake as a potential adaptation to diurnality. Journal of Experimental Biology, 220: 2418-2425. PDF.

Dungan, S.Z. & Chang, B.S.W. (2017). Epistatic interactions influence terrestrial–marine functional shifts in cetacean rhodopsin. Proceedings of the Royal Society B, 284: 20162743. PDF.

Schott, R.K., Panesar, B., Card, D.C., Preston, M., Castoe, T.A. & Chang, B.S.W. (2017). Targeted capture of complete coding regions across divergent species. Genome Biology and Evolution, 9(2):398-414.PDF.

Morrow, J.M., Lazic, S., Dixon Fox, M., Kuo, C., Schott, R.K., Gutierrez, E.A., Santini, F., Tropepe, V. & Chang, B.S.W. (2017). A second visual rhodopsin gene, rh1-2, is expressed in zebrafish photoreceptors and found in other ray-finned fishes. Journal of Experimental Biology, . PDF.

Luk, H.L., Bhattacharyya, N., Montisci, F., Morrow, J.M., Melaccio, F., Wada, A., Sheves, M., Fanelli, F., Chang, B.S.W. & Olivucci, M. (2016). Modulation of thermal noise and spectral sensitivity in Lake Baikal cottoid fish rhodopsins. Scientific Reports, 6:38425. PDF.

Di Roberto, R.B., Chang, B.S.W., Trusina, A. & Peisajovich, S.G. (2016). Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions. Nature Communications, 7:12344. PDF.

van Hazel, I., Dungan, S.Z., Hauser, F.E., Morrow, J.M., Endler, J.A. & Chang, B.S.W. (2016). A comparative study of rhodopsin function in the great bowerbird (Ptilonorhynchus nuchalis): Spectral tuning and light-activated kinetics. Protein Science, 25 (7): 1308-1318. PDF.

Elbassiouny, A.A., Schott, R.K., Waddell, J.C., Kolmann, M.A., Lehmberg, E.S., Van Nynatten, A., Crampton, W.G.R., Chang, B.S.W. &  Lovejoy N.R. (2016). Mitochondrial genomes of the South American electric knifefishes (Order Gymnotiformes). Mitochondrial DNA Part B: Resources, 1 (1): 401-403. PDF.

Gutierrez, E.A., Van Nynatten, A., Lovejoy, N.R. & Chang, B.S.W. (2016). Sensory Systems: Molecular Evolution in Vertebrates In The Encyclopedia of Evolutionary Biology, Kliman, R.M. (ed.), Oxford: Academic Press, 4: 30-33. PDF.

Dungan, S.Z., Kosyakov, A. & Chang, B.S.W. (2016). Spectral tuning of killer whale (Orcinus orca) rhodopsin: Evidence for positive selection and functional adaptation in a cetacean visual pigment. Molecular Biology and Evolution, 33 (2)323-336.PDF.

Hauser, F.E., Schott, R.K., Castiglione, G.M., Van Nynatten, A., Kosyakov, A., Tang, P.L., Gow, D.A. & Chang, B.S.W. (2016). Comparative sequence analyses of rhodopsin and RPE65 reveal patterns of selective constraint across hereditary retinal disease mutations. Visual Neuroscience, 33: e002. PDF.

Schott, R.K., Müller, J., Clement Y.G.Y., Bhattacharyya, N., Chan, N., Xua, M., Morrow, J.M., Ghenu, A.H., Loew, E.R., Tropepe, V. & Chang, B.S.W. (2016). Evolutionary transformation of rod photoreceptors in the all-cone retina of a diurnal garter snake. Proceedings of the National Academy of Sciences of the United States of America, 113(2): 356-361. PDF.

Bickelmann, C., Morrow, J.M, Du, J., Schott, R.K., van Hazel, I., Lim, S., Müller, J. & Chang, B.S.W. (2015). The molecular origin and evolution of dim-light vision in mammals. Evolution, 69(11): 2995-3003. PDF.

Bloch, N.I., Price, T.D. & Chang, B.S.W. (2015). Evolutionary dynamics of Rh2 opsins in birds demonstrate an episode of accelerated evolution in the New World warblers (Setophaga). Molecular Ecology, 24(10): 2449-2462. PDF.

Morrow, J.M. & Chang, BS.W. (2015). Comparative mutagenesis studies of retinal release in light-activated zebrafish rhodopsin using fluorescence spectroscopy. Biochemistry, 54(29):4507-4518.PDF.

Van Nynatten, A. Bloom, D., Chang. B.S.W. & Lovejoy, N. (2015). Out of the Blue: adaptive visual pigment evolution accompanies Amazon invasion. Biology Letters, 11(7):20150349.PDF.

Bloch, N.I., Morrow, J.M., Chang, B.S.W. & Price, T.D. (2015). SWS2 visual pigment evolution as a test of historically contingent patterns of plumage color evolution in warblers. Evolution, 69(2):341-356. PDF.

Hauser, F.E., van Hazel, I. & Chang B.S.W. (2014). Spectral tuning in vertebrate short wavelength sensitive 1 (SWS1) visual pigments: Can wavelength sensitivity be inferred from sequence data? Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 322(7):529-539. PDF.

Du, J., Dungan, S.Z., Sabouhanian, A. & Chang B.S.W. (2014). Selection on synonymous codons in mammalian rhodopsins: a possible role in optimizing translational processes. BMC Evolutionary Biology, 14:96. PDF Suppl 1 Suppl 2 Suppl 3

Lovejoy, D.A., Chang, B.S.W., Lovejoy, N.R. & del Castillo J. (2014). Molecular evolution of GPCRs: CRH/CRH receptors. Journal of Molecular Endocrinology, 52:T43-60. PDF

Schott, R.K., Refvik, S.P., Hauser, F.E., Lopez-Fernandez, H. & Chang B.S.W. (2014). Divergent Positive Selection in Rhodopsin from Lake and Riverine Cichlid Fishes. Molecular Biology and Evolution, 31(5):1149-1165. PDF Suppl. Info

Chang, B.S.W. (2014). Ancient insights into uric acid metabolism in primates. Proceedings of the National Academy of Sciences of the United States of America, 111(10):3657-3658. PDF

Williams, R., Ma, X., Schott, R.K., Mohammad, N., Ho, C.Y., Li, C.F., Chang, B.S.W., Demetriou, M. & Dennis, J.W. (2014). Encoding Asymmetry of the N-Glycosylation Motif Facilitates Glycoprotein Evolution. PLoS ONE, 9(1):e86088. PDF

Castoe, T.A., de Koning, A.P., Hall, K.T. Card, D.C., Schield, D.R., Fujita, M.K., Ruggiero, R.P., Degner, J.F., Daza, J.M., Gu, W., Reyes-Velasco, J., Shaney ,K.J., Castoe, J.M., Fox, S.E., Poole, A.W., Polanco, D., Dorby, J., Vandewege, M.W., Li, Q., Schott, R.L., Kapusta, A., Minx, P., Feschotte, C., Uetz, P., Ray, D.A., Hoffmann, F.G., Bogden, R., Smith, E.N., Chang, B.S.W., Vonk, F.J., Casewell, N.R., Henkel C.V., Richardson, M.K., Mackessy, S.P., Bronikowski, A.M., Yandell, M., Warren, W.C., Secor, S.M. & Pollock, D.D. (2013). The Burmese python genome reveals the molecular basis for extreme adaptation in snakes. Proceedings of the National Academy of Sciences of the United States of America, 110(51):20645-20650. PDF

van Hazel, I., Sabouhanian, A., Day, L., Endler, J.A. & Chang B.S.W.(2013). Functional characterization of spectral tuning mechanisms in the great bowerbird short-wavelength sensitive visual pigment (SWS1) and the origins of UV/violet vision in passerines and parrots. BMC Evolutionary Biology, 13:250. PDF Suppl. Info

Lin, Y.G., Weadick, C.J., Santini, F. & Chang, B.S.W. (2013). Molecular Evolutionary Analysis of Vertebrate Transducins: A Role for Amino Acid Variation in Photoreceptor Deactivation. Journal of Molecular Evolution, 77(5-6):231-245. PDF

Weadick, C.J. & Chang, B.S.W. (2012). Complex patterns of divergence among green-sensitive (RH2a) African cichlid opsins revealed by Clade model analyses. BMC Evolutionary Biology, 12:206. PDF

Weadick, C.J., Loew, E.R., Rodd, F.H. & Chang, B.S.W. (2012). Visual pigment molecular evolution in the Trinidadian pike cichlid (Crenicichla frenata): A less colourful world for Neotropical cichlids? Molecular Biology and Evolution, 29(10):3045-3060. PDF

Bickelmann, C., Morrow, J.M, Müller, J., & Chang, B.S.W. (2012). Functional characterization of the rod visual pigment of the echidna (Tachyglossus aculeatus), a basal mammal. Visual Neuroscience, 29:211-217. PDF

Weadick, C.J., & Chang B.S.W. (2012). An improved likelihood ratio test for detecting site-specific functional divergence among clades of protein-coding genes. Molecular Biology and Evolution, 29(5):1297-1300. PDF Errata

Chang, B.S.W., Du, J., Weadick, C., Müller, J., Bickelmann, C., Yu, D.D., & Morrow, J.M. (2012). The future of codon models in studies of molecular evolution: Ancestral reconstruction, and clade models of functional divergence. In Codon Evolution: Mechanisms and Models, G.M. Cannarozzi, A. Schneider (eds.), Oxford University Press, pp. 145-163. PDF

Hult, E.F., Tobe, S.S. & Chang, B.S.W. (2011). Molecular evolution of ultraspiracle protein (USP/RXR) in insects. PLoS ONE, 6(8): e23416. PDF

Morrow, J.M., Lazic, S., & Chang, B.S.W. (2011). A novel rhodopsin-like gene expressed in zebrafish retina. Visual Neuroscience, 28:325-335. PDF

Martínez-Pérez, F., Bendena, W.G., Chang, B.S.W. & Tobe S.S. (2011). Influence of codon usage bias in FGLamide-Allatostatin mRNA secondary structure. Peptides, 32:509-517. PDF

Morrow, J.M., & Chang, B.S.W. (2010). The p1D4-hrGFP II expression vector: a tool for expressing and purifying visual pigments and other G protein-coupled receptors. Plasmid, 64(3):162-169. PDF

Wong, L., Weadick, C.J., Kuo, C., Chang, B.S.W., & Tropepe, V.(2010). Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development. BMC Developmental Biology, 10:100. PDF

Koehler, A., Desser, S., Chang, B.S.W., MacDonald, J., Tepass, U., & Ringuette, M. (2009). Molecular evolution of SPARC: absence of the acidic module and expression in the endoderm of the starlet sea anemone, Nematostella vectensis. Development, Genes and Evolution, 219:509-521. PDF

Weadick, C.J. & Chang, B.S.W. (2009). Molecular evolution of the βγ lens crystallin superfamily: evidence for a retained ancestral function in γN crystallins? Molecular Biology and Evolution 26:1127-1142. PDF

Martinez-Perez, F., Bendena, W.G., Chang, B.S.W. & Tobe S.S. (2009). FGLamide-Allatostatin gene in Arthropoda: Introns early or late? Peptides, 30(7):1241-1248. PDF

Hult, E.F., Weadick, C.J., Chang, B.S.W. & Tobe, S.S.(2008). Reconstruction of ancestral FGLamide-type insect allatostatins: A novel approach to the study of allatostatin function and evolution. Journal of Insect Physiology, 54(6):959-968. PDF

Lenkic, L.E., Wolfe, J., Chang, B.S.W. & Tobe, S.S. (2008). Endocrine and reproductive differences and genetic divergence in two populations of the cockroach Diploptera punctata. Journal of Insect Physiology, 54(6):931-938. PDF

Weadick, C.J. & Chang, B.S.W.(2007). Long-wavelength sensitive visual pigments of the guppy (Poecilia reticulata): six opsins expressed in a single individual. BMC Evolutionary Biology, 7 (Suppl. 1):S11. PDF

Chang, B.S.W., Matz, M.V., Field, S.F., Müller, J. & van Hazel, I. (2007). Dealing with model uncertainty in reconstructing ancestral proteins in the laboratory: Examples from ancestral visual pigments and GFP-like proteins. In Ancestral Sequence Reconstruction, D.A. Liberles (ed.), Oxford University Press. PDF

Pollock, D.D. & Chang, B.S.W. (2007). Dealing with uncertainty in ancestral sequence reconstruction: sampling from the posterior distribution. In Ancestral Sequence Reconstruction, D.A. Liberles (ed.), Oxford University Press. PDF

Kuang, D., Yao, Y., MacLean, D., Wang, M., Hampson, D.R. & Chang B.S.W. (2006). Ancestral reconstruction of the ligand binding pocket of family C G-protein coupled receptors. Proceedings of the National Academy of Sciences of the United States of America, 103(38):14050-14055. PDF

van Hazel, I., Santini, F., Müller, J. & Chang, B.S.W (2006). Short-wavelength sensitive opsin (SWS1) as a new marker for vertebrate phylogenetics. BMC Evolutionary Biology, 6:97. PDF

Chang B.S.W., Ugalde J.A. & Matz M.V. (2005). Applications of ancestral protein reconstruction in understanding protein function: GFP-like proteins. Methods in Enzymology, 395: 652-670. PDF

Ugalde J.A., Chang B.S. & Matz M.V. (2004). Evolution of coral pigments recreated. Science, 305(5689):1433. PDF

Yan, E.C.Y., Ganim, Z., Kazmi, M.A., Chang, B.S.W., Sakmar, T.P. & Mathies R.A. (2004). Resonance Raman analysis of the mechanism of energy storage and chromophore distortion in the primary visual photoproduct. Biochemistry, 43:10867-10876. PDF

Chang, B.S.W. (2003). Ancestral gene reconstruction and synthesis of ancient rhodopsins in the laboratory. Integrative and Comparative Biology, 43:500-507. PDF

Yan, E.C.Y., Kazmi, M.A., Ganim, Z., Hou, J.-M., Pan, D., Chang, B.S.W., Sakmar, T.P. & Mathies, R.A. (2003). Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin. Proceedings of the National Academy of Sciences of the United States of America, 100(16):9262-9267. PDF
Commentary by Robert R. Birge and Barry E. Knox. PDF

Chang, B.S.W., Jönsson, K., Kazmi, M.A., Donoghue, M.J. & Sakmar T.P. (2002). Recreating a functional ancestral archosaur visual pigment. Molecular Biology and Evolution, 19(9):1483-1489. PDF

Chang, B.S.W., Kazmi, M.A., & Sakmar, T.P. (2002). Synthetic gene technology: Applications to ancestral gene reconstruction and structure-function studies of receptors. Methods in Enzymology, 343:274-294. PDF

Yan, E.C.Y., Kazmi, M.A., De, S., Chang, B.S.W., Seiburt, C., Marin, E.P., Mathies, R.A. & Sakmar, T.P. (2002). Function of extracellular loop 2 in rhodopsin: Glutamic acid 181 modulates stability and absorption wavelength of metarhodopsin II. Biochemistry, 41(11):3620-3627. PDF

Lindahl, P.A. & Chang, B.S.W (2001). Evolution of acetyl-CoA synthase. Origins of Life and Evolution of the Biosphere, 31(4/5): 403-434. PDF

Hsu, R., Briscoe, A.D., Chang, B.S.W. & Pierce, N.E. (2001). Molecular evolution of a long wavelength-sensitive opsin in mimetic Heliconius butterflies (Lepidoptera: Nymphalidae). Biological Journal of the Linnaean Society, 72:435-449. PDF

Chang, B.S.W. & Campbell, D.L. (2000). Bias in phylogenetic reconstruction of vertebrate rhodopsin sequences. Molecular Biology and Evolution, 17(8):1220-1231. PDF

Chang, B.S.W. & Donoghue, M.L. (2000). Recreating ancestral proteins. Trends in Ecology and Evolution, 15(3):109-114. PDF

Hughes, L., Chang, B.S.W., Wagner, D. & Pierce, N.E. (2000). Effects of mating history on ejaculate size, fecundity, longevity, and copulation duration in the ant-tended lycaenid butterfly, Jalmenus evagoras. Behavioral Ecology and Sociobiology, 47:119-128. PDF

JNeurosci-coverTownson, S.M., Chang, B.S.W., Salcedo, E., Chadwell, L., Pierce, N.E. & Britt, S.G. (1998). Isolation and physiological characterization of the genes encoding the blue and ultraviolet sensitive opsins of the honeybee, Apis mellifera. Journal of Neuroscience, 18(7):2412-2422. PDF

Chang, B.S.W., Ayers, D., Smith, W.C. & Pierce, N.E. (1996). Cloning of the gene encoding honeybee long-wavelength rhodopsin: a new class of insect visual pigments. Gene, 173:215-219. PDF

Chang, B.S.W., Crandall, K.A., Carulli, J.P. & Hartl, D.L. (1995). Opsin phylogeny and evolution: a model for blue shifts in wavelength regulation. Molecular Phylogenetics and Evolution, 4(1):31-43. PDF

Ayala, F.J., Chang, B.S.W. & Hartl D.L., (1993). Molecular evolution of the Rh3 gene in Drosophila. Genetica, 92(1):23-32. PDF

Ruvolo, M., Zehr, S., von Dornum, M., Pan, D., Chang, B.S.W. & Lin, J.(1993). Mitochondrial COII sequences and modern human origins. Molecular Biology and Evolution, 10(6):1115-1135. PDF