Pathogenic mutations cause rhodopsin to misfold and disrupt its function. In this study, a yeast-based assay was used to screen for compounds that have the potential to rescue the function of mutant rhodopsin. It was confirmed that 9-cis retinal could partially rescue light-dependent activation of disease-associated rhodopsin mutation (P23H). A phenotypic screen was also done with yeast assays to screen compounds from the LOPAC1280 library and a peptidomimetic library.
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Recent Posts
- Scaling up functional analyses of the G protein-coupled receptor rhodopsin March 13, 2024
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- Multiple ecological axes drive molecular evolution of cone opsins in Beloniform fishes March 13, 2024
- Adaptive evolution of nearctic deepwater fish vision: implications for assessing functional variation for conservation March 13, 2024
- Convergent Evolution of Dim Light Vision in Owls and Deep-Diving Whales November 28, 2023
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