Pathogenic mutations cause rhodopsin to misfold and disrupt its function. In this study, a yeast-based assay was used to screen for compounds that have the potential to rescue the function of mutant rhodopsin. It was confirmed that 9-cis retinal could partially rescue light-dependent activation of disease-associated rhodopsin mutation (P23H). A phenotypic screen was also done with yeast assays to screen compounds from the LOPAC1280 library and a peptidomimetic library.
- Convergent Evolution of Dim Light Vision in Owls and Deep-Diving Whales November 28, 2023
- Chang Lab and colleagues receive Human Frontier Science Program grant to pursue studies into the evolution of the multifunction rhodopsin protein November 28, 2023
- Whales Evolved Swiftly to Become Deep Divers July 7, 2022
- This Fish Has Adapted to Canada’s Deepest Coldest Lakes. UTSC Researchers are Unravelling it’s Genetics to Find Out How. July 7, 2022
- Convergent patterns of evolution of mitochondrial oxidative phosphorylation (OXPHOS) genes in electric fishes January 16, 2020
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