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Recent Posts
- Undergraduate Research Spotlight: Alena Qin Excels in Chang Lab ROP Project March 17, 2025
- Sampling Strategies for Experimentally Mapping Molecular Fitness Landscapes Using High-Throughput Methods August 12, 2024
- Evolution of rhodopsin in flatfishes (Pleuronectiformes) is associated with depth and migratory behavior June 26, 2024
- Scaling up functional analyses of the G protein-coupled receptor rhodopsin March 13, 2024
- Evolution of a novel regulatory mechanism for hypoxia tolerance in electric fishes March 13, 2024
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Author Archives: Chang Lab
Directed evolution of ligand specificity in a GPCR
A study by Raphaël Di Roberto, Belinda Chang and Sergio Peisajovich demonstrated that changes in ligand efficacy can lead to changes in GPCR specificity, eliminating the need for extensive binding pocket re-modeling. Read their paper published in Scientific Reports to … Continue reading
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