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Recent Posts
- Undergraduate Research Spotlight: Alena Qin Excels in Chang Lab ROP Project March 17, 2025
- Sampling Strategies for Experimentally Mapping Molecular Fitness Landscapes Using High-Throughput Methods August 12, 2024
- Evolution of rhodopsin in flatfishes (Pleuronectiformes) is associated with depth and migratory behavior June 26, 2024
- Scaling up functional analyses of the G protein-coupled receptor rhodopsin March 13, 2024
- Evolution of a novel regulatory mechanism for hypoxia tolerance in electric fishes March 13, 2024
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Author Archives: Chang Lab
Screening of Chemical Libraries Using a Yeast Model of Retinal Disease
Pathogenic mutations cause rhodopsin to misfold and disrupt its function. In this study, a yeast-based assay was used to screen for compounds that have the potential to rescue the function of mutant rhodopsin. It was confirmed that 9-cis retinal could … Continue reading
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