Steven K. Chen

Steven K. Chen

PhD Student
Department of Cell and Systems Biology
University of Toronto
25 Harbord St., Toronto, ON M5S 3G5

Email: stevenk.chen@mail.utoronto.ca
Twitter: @steve_kuanyu

Current Research

  • Current projects aim to identify principles of protein evolution and to determine how these principles shape the evolution of signaling networks in cells
  • Insights learned and technologies developed during these projects are applied to engineer biological systems for diverse applications

Education

Ph.D. Candidate (2018-Present) — University of Toronto, Cell & Systems Biology

H.B.Sc. (2018) — University of Toronto, Molecular Genetics & Microbiology and Immunology

Academic Awards

  • David F. Mettrick Fellowship, 2021
  • Endowed Ontario Graduate Scholarship, 2021-Present
  • Young Investigator Award – Society for Molecular Biology and Evolution, 2020
  • Vision Science Research Program Award, 2019-Present
  • University of Toronto Fellowship, 2018-Present
  • Zoology Sesquicentennial Graduate Award, 2018
  • Cell and Systems Biology Undergraduate Research Day – F. Michael Barrett Award for Best Poster, 2018
  • University of Toronto Arts & Science – Undergraduate Research Fund, 2018

Publications

  • Scott, B.M.*, Gutiérrez-Vázquez, C.*, Sanmarco, L.M., de Silva Pereira, J.A., Li, Z., Plasencia, A., Hewson, P., Cox, L.M., O’Brien, M., Chen, S.K., Moraes-Vieira, P.M., Chang, B.S.W., Peisajovich S.G., & Quintana, F.J. (2021). Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease. Nature Medicine. 27(7): pp. 1212–1222. https://doi.org/10.1038/s41591-021-01390-x
  • Scott B.M., Chen S.K., Bhattacharyya N., Heon, E., Moalim A.Y., Plotnikov S.V., Peisajovich S.G., Chang B.S.W. (2019). Coupling of Human Rhodopsin to a Yeast Signaling Pathway Enables High-Throughput Characterization of Mutations Associated with Retinal Disease. Genetics, 211(2), pp. 597–615. doi: 10.1534/genetics.118.301733.

Selected Contributed Presentations

  • Chen S.K., Scott B.M., Van Nynatten A., Scott R.K., Peisajovich S., Heon E., Chang B.S.W. 2021. Mutational constraints on a transmembrane protein revealed by deep scanning mutagenesis. Symposium for Molecular Biology & Evolution. Society for Molecular Biology & Evolution, Virtual Conference (Oral presentation)
  • Chen S.K., Scott B.M., Van Nynatten A., Scott R.K., Peisajovich S., Heon E., Chang B.S.W. 2021. Functional constraints on a transmembrane protein revealed by deep scanning mutagenesis. Virtual Evolution 2021, Virtual Conference (Oral presentation)
  • Chen S.K., Jing L., Chang B.S.W. 2021. Multi-dimensional mutational scans of G protein-coupled receptors. Vision Sciences 63rd Annual Research Day. University Health Network & University of Toronto Department of Vision Science, Virtual Conference (Oral presentation)
  • Chen S.K., Jing L., Chang B.S.W. 2021. Investigating the molecular evolution of transmembrane proteins using high-throughput genetic approaches, International T3 Molecular Evolution Symposium (TelAviv, Toronto, Temple). Virtual Conference (Oral Presentation)
  • Chen S.K., Scott B.M., Van Nynatten A., Scott R.K., Peisajovich S., Heon E., Chang B.S.W. 2020. A Deep mutational scanning approach to studying GPCR genetic variation and sequence-function relationships, European Molecular Biology Laboratory Conference: Molecular Mechanisms in Evolution & Ecology. Virtual Conference (Poster)
  • Chen S.K., Scott B.M., Van Nynatten A., Schott R.K., Peisajovich S., Heon E., Chang B.S.W. 2020. A high-throughput system in yeast for studying the relationship between GPCR genetic variation & function. Vision Science 62nd Annual Research Day, University Health Network & University of Toronto Department of Vision Science. Virtual Conference (Oral Presentation)
  • Chen S.K., Scott B.M., Van Nynatten A., Schott R.K., Peisajovich S., Heon E., Chang B.S.W. 2020. A high-throughput system for studying the relationship between GPCR genetic variation & function. Symposium for Molecular Biology & Evolution, Québec City, QC (Poster – Cancelled due to COVID-19 Pandemic)
  • Chen S.K., Scott B.M., Bhattacharyya N. Peisajovich S., Chang B.S.W. 2019.
    High-throughput Investigation of Rhodopsin Function using Yeast. Biophysical
    Society of Canada Annual Meeting, University of Toronto Mississauga,
    Mississauga ON. (Oral Presentation & Poster)
  • Chen S.K., Scott B.M., Peisajovich S., Chang B.S.W. 2018. Engineering a Yeast Platform for Characterizing Rhodopsin Variants of Uncertain Significance. International Conference for Retinal Proteins, Hockley Valley Resort, Mono ON. (Poster)
  • Chen S.K., Scott B.M., Chang B.S.W. 2018. High-Throughput Characterisation of Rhodopsin of Rhodopsin: A Functional Assessment. Cell Systems Biology Undergraduate Research Day, University of Toronto, Toronto ON. (Poster)