Benjamin M. Scott

Benjamin M. Scott

Ph.D. Student
Department of Cell and Systems Biology
University of Toronto
25 Harbord St., Toronto, ON, M5S 3G5



Current Research

  • Heterologous expression of functional GPCRs using the yeast S. cerevisiae
  • Rapid characterisation of mutations relevant to disease
  • GPCR mutagenesis and engineering


Ph.D. (2013 – present) — University of Toronto, Cell and Systems Biology
Thesis: Novel biological circuits in S. cerevisiae

M.Sc. (2013) — McMaster University, Medical Sciences (Blood & Vasculature)
Thesis: Applying phage display to screen a library of α1-proteinase inhibitor mutants for improved thrombin binding activity

H.B.Sc. (2011) — McMaster University, Life Sciences (Origins)
Thesis: Replicating fibrinolysis in vitro using a bacterial co-secretion system

Academic Awards

Ontario Graduate Scholarship, 2016, 2015, 2013
Kenneth C. Fisher Fellowship, 2015
Aiken-Woods Memorial Graduate Scholarship in Cell and Systems Biology, 2014
Cell & Systems Biology Entrance Award, 2013
Kiwanis Club Scholarship (Graduate), 2011, 2008
Dean’s Honour List, 2011, 2010
University Senate Scholarship, 2010
McMaster Entrance Scholarship, 2007

Peer-Reviewed Journal Publications

Di Roberto RB, Scott BM, Peisajovich SG. (in press) Directed Evolution Methods to Rewire Signaling Networks. Methods in Molecular Biology.

Scott BM, Matochko WL, Gierczak RF, Bhakta V, Derda R, Sheffield WP. (2014) Phage display of the serpin alpha-1 proteinase inhibitor randomized at consecutive residues in the reactive centre loop and biopanned with or without thrombin. PLoS ONE, 9(1): e84491. doi:10.1371/journal.pone.0084491

Other Publications and Presentations

Scott BM, Chang BSW, Peisajovich SG. (2016) Directed Evolution of a Purinergic GPCR to Improve Sensitivity to Extracellular ATP. Poster session presented at: 2nd Protein Engineering Canada Conference, Ottawa, ON.

Scott BM. (2016) Perspectives on Synthetic Biology and Engineering Novel Biological Circuits. Invited Speaker at: MGEM Synthetic Biology Speaker Series; McMaster University.

Scott BM. (2015) Yeast, GPCRs, and you. Public lecture at: Cell and Systems Biology Research Day; University of Toronto.

Scott BM. (2013) Commentary: High-throughput screening and the rational design of anticoagulants. McMaster University Medical Journal, 10(1): 29-32

Scott BM, Gierczak RF, Bhakta V, Sheffield WP. (2013) Applying phage display for improved engineering of therapeutic serine protease inhibitors. Poster session presented at: 9th Annual Protein Engineering Summit; Boston, MA. And at the XXIV International Society of Thrombosis and Haemostasis Congress; Amsterdam, Netherlands.

Scott BM. (2013) Protein Engineering. Public lecture at: Interdisciplinary Research Conference; McMaster University.

Scott BM, Sheffield WP, Stone JR. (2011) Replicating fibrinolysis in vitro using a bacterial co-secretion system. Public lecture at: Origins Research Colloquium; McMaster University.